Endocrine Abstracts

Background: Insulin resistance and dyslipidemia inobese subjectsare important for predicting future cardiovascular risk. Purpose of the study was to analyze the lipid profile of obese children depending on gender and insulin resistance status.Subjects and methods: 247 overweight and obese children (160 boys and 87 girls) aged 2 to 18 y.o. were examined in the pediatric endocrinology department. Lipids assessment included measurement of total cholest...

Growth hormone deficiency (GHD) in children is a rare, aetiologically diverse condition that results in growth failure and short stature. Inadequate response to two different growth hormone stimulation tests (GHST) is required for the diagnosis of GHD. Macimorelin acetate, a potent, orally administered growth hormone (GH) secretagogue, is approved by the FDA and EMA for the diagnosis of adult GHD. Study AEZS-130-P01 is the first of two studies to investigate macimorelin acetat...